陈宏斌
北京大学人民医院
北京大学人民医院,检验科,副研究员,全国细菌耐药监测学术委员会青年委员会副主任委员,中国医疗保健国际交流促进会临床微生物与感染分会常务委员,北京微生物学会理事,北京药理学会抗感染药理专业委员会青年委员。主要从事临床微生物学检验、细菌耐药监测及细菌耐药机制研究。 曾获第五届北京大学人民医院学术新星三等奖。以第一作者发表SCI文章13篇,总影响因子48分,以第一作者发表中文文章7篇。
主持科研课题:
国家自然科学基金面上项目(项目批准号:81471990)、
国家自然科学基金青年基金(项目批准号:31100106)、
北京市自然科学基金(项目批准号:7143185)
北京大学人民医院研究与发展基金(项目批准号:RDB2013-09)。
受教育经历
2007/09-2010/07,北京协和医学院,北京协和医院,医学硕士
1999/09-2004/07,四川大学华西医学中心,临床医学院,医学学士同时修第二专业软件工程
研究工作经历
2010/08-2012/04,北京协和医院检验科,实习研究员
2012/05-2013/08,北京大学人民医院检验科,实习研究员
2013/09-2017/08,北京大学人民医院检验科,助理研究员
2017/10-2018/10 ,University College London访问学者
2017/09-至今, 北京大学人民医院检验科,副研究员
主要论著
发表文章19篇,其中以第一作者在SCI期刊发表论文13篇,总影响因子48分。
期刊论文:
Hongbin Chen, Qi Wang, Yuyao Yin, Shuguang Li, Dengke Niu, Hui Wang. Genotypic variations between wild-type and small colony variants of staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. Int J Antimicrob Agents. 2018, 51(4):655-658. (SCI IF=4.415)
Hongbin Chen, Xiong Z, Liu K, Li S, Wang R, Wang X, Zhang Y, Wang H. Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance. Int J Antimicrob Agents. 2016, 47(5):362-7. (SCI IF=4.415)
Hongbin Chen, Wang Z, Li H, Wang Q, Zhao C, He W, Wang X, Zhang F, Wang H. In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China. Jpn J Infect Dis. 2015;68(4):263-7. (SCI IF=1.14)
Hongbin Chen, Xi Yang, Qi Wang, et al. Insights on Evolution of Virulence and Resistance from the Wholegenome Analysis of a Predominant Methicillin-resistant Staphylococcus aureus Clone Sequence Type 239 in China. CHINESE SCI BULL. 2014, 59(11):1104-1112. (SCI IF=1.319)
Hongbin Chen, Qing Yang, Rong Zhang, et al. In-vitro antimicrobial activity of a novel oxazolidinone tedizolid and other comparators against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicenter study in China. Int J Antimicrob Agents, 2014,44(3):276-7. (SCI IF=4.415)
Hongbin Chen, Weiyuan Wu, Ming Ni, Yingmei Liu, Jixia Zhang, Fei Xia, Wenqiang He, Qi Wang, Zhanwei Wang, Bin Cao, Hui Wang*. Linezolid-resistant clinical isolates of enterococci and staphylococcus cohnii from a multicentre study in china: Molecular epidemiology and resistance mechanisms. Int J Antimicrob Agents, 2013;42:317-321. (SCI IF=4.415)
Wenqiang He*, Hongbin Chen*, Chunjiang Zhao, Feifei Zhang,Henan Li, Qi Wang, Xiaojuan Wang, Hui Wang*. Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes. Int J Antimicrob Agents, 2013, 42(3): 211-219. (SCI IF=4.415, 并列第一作者)
Hongbin Chen, Yali Liu, Chunjiang Zhao, Di Xiao, Jianzhong Zhang, Feifei Zhang, Minjun Chen, Hui Wang*. Comparative Proteomics-Based Identification of Genes Associated with Glycopeptide Resistance in Clinically Derived Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Strains. Plos One 2013, 8(6):e66880. (SCI IF=3.73)
Hongbin Chen, Yudong Liu, Wenjia Sun, et al. The incidence of heterogeneous vancomycin-intermediate Staphylococcus aureus correlated with increase of vancomycin MIC. Diagn Microbiol Infect Dis. 2011, 71(3):301-303. (SCI IF=2.451)
Hongbin Chen, Hui Wang, Yudong Liu, et al. Rapid change of methicillin-resistant Staphylococcus aureus clones in a tertiary care hospital of China over a fifteen-year period. Antimicrob Agents Chemother, 2010, 54: 1842-1847. (SCI IF=4.716)
Wenjia Sun*, Hongbin Chen*, Yudong Liu, et al. Prevalence and characterization of heteroresistant vancomycin-intermediate resistant Staphylococcus aureus (hVISA) isolates from 14 cities in China. Antimicrob Agents Chemother, 2009 53: 3642-3649. (SCI IF=4.716,并列第一作者)
Hong Yang*, Hongbin Chen*, Qiwen Yang, et al. High Prevalence of plasmid-mediated quinolone Resistance Genes qnr and aac(6`_)-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Antimicrob Agents Chemother, 2008, 52: 4268–4273. (SCI IF=4.716,并列第一作者)
Henan Li*, Chunjiang Zhao*, Hongbin Chen*, et al. Identification of gene clusters associated with host adaptation and antibiotic resistance in Chinese Staphylococcus aureus isolates by microarray-based comparative genomics. Plos One. 2013, 8(1):e53341.(SCI IF=3.73, 并列第一作者)
陈宏斌,赵春江,王辉,等. 2011年中国13家教学医院院内获得性细菌耐药性分析. 中华内科杂志. 2013年3月第52卷第3期.
陈宏斌,王辉,孙闻嘉,等. 2007年中国14个城市分离的异质性万古霉素中介耐药的耐甲氧西林金黄色葡萄球菌分子特征. 中华检验医学杂志. 2009, 32 (11): 1223-1227.
陈宏斌,王辉. 万古霉素敏感性下降的金黄色葡萄球菌研究进展. 中华检验医学杂志. 2009, 32(11): 1214-1217.
陈宏斌,杨启文,陈民钧,等. 头孢噻利对临床常见细菌体外抗菌活性的多中心研究. 中国感染与化疗杂志. 2011, 11(4): 256-263.
陈宏斌, 张小江, 赵颖, 等. 卫生部全国细菌耐药监测网(Mohnarin) 2009年度报告: ICU来源细菌耐药监测. 2011, 27(7): 483-489.
陈宏斌 黄加铭 杨青等. 43株利奈唑胺耐药葡萄球菌耐药机制研究. 中华检验医学杂志, 2016,39(11):848-851.
陈宏斌;赵春江;王辉等. 2007-2013年医院内获得性肺炎病原菌分布及其耐药性分析. 中华医院感染学杂志, 2017, (01) 1-7.